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2020| July-September | Volume 21 | Issue 3
Online since
June 30, 2020
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CASE REPORTS
Dermoscopy of nevus comedonicus: A case series
Payal Chauhan, Dilip Meena, Shilpi Sharma
July-September 2020, 21(3):232-234
DOI
:10.4103/ijpd.IJPD_29_20
Nevus comedonicus (NC) is an uncommon condition which belongs to the spectrum of the epidermal nevi syndrome. Dermoscopy is a non-invasive tool which can help to rule out other differential diagnoses, making it especially valuable in pediatric cases. We present three children with NC and describe their dermoscopic findings.
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RESIDENTS CORNER
Use of antifungals in pediatric superficial dermatophytosis
Grishma R Gandhi, Resham J Vasani
July-September 2020, 21(3):235-240
DOI
:10.4103/ijpd.IJPD_33_20
There has been a rise in the incidence of dermatophytic infections in children in the last decade. Additionally, there has been a sea change in the clinical presentation, treatment practices and course of the condition seen in practice. This article summarises information on the available topical and oral antifungal agents in question and asnwer format for better understanding.
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CASE REPORTS
Topical steroid – An effective treatment for physiologic phimosis in children
Vikrant A Saoji
July-September 2020, 21(3):184-186
DOI
:10.4103/ijpd.IJPD_3_20
Asymptomatic phimosis is normal in young children which self-corrects itself but leads to parental anxiety. Topical steroids lead to correction of this physiologic phimosis avoiding the need of circumcision. Six male children aged between 3 and 14 years presented with asymptomatic tight phimosis present since birth. All the children were advised application of small amount of clobetasol propionate cream at night along with manual retraction during bath. At the end of 2 months, all the children had fully retractable prepuce. By the first visit (2 weeks), all the patients showed at least partial retractability of the prepuce. Till the follow-up period of 6 months, there was no recurrence in any patient. No side effects were observed.
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Report of an autosomal recessive epidermolytic ichthyosis
KS Chandan, SR Ashitha, Sachin Somashekhar, L Shishira
July-September 2020, 21(3):221-223
DOI
:10.4103/ijpd.IJPD_102_19
Epidermolytic ichthyosis (EI) previously named bullous congenital ichthyosiform erythroderma of Brocq or epidermolytic hyperkeratosis (mostly considered as a histological term now) is rare with a variable defect of cornification, clinically characterized by generalized erythema, erosions, scaling, and easily breaking blisters that become less frequent later in life while hyperkeratosis increases. It is usually inherited in an autosomal-dominant fashion and is caused by the mutations in the genes KRT1 and KRT10, coding for the proteins keratin 1 and keratin 10, respectively. To date, only six recessive KRT10 mutations have been shown to cause autosomal-recessive EI, all of which have been found to lead to the complete absence of the keratin 10 protein. To the best of our knowledge, this is the first such case report from India.
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ORIGINAL ARTICLES
Zinc has a role in pathogenesis of pityriasis alba
Fatma M Elesawy, Essam M Akl, Walid A Abdel Halim
July-September 2020, 21(3):178-183
DOI
:10.4103/ijpd.IJPD_109_19
Background:
Pityriasis alba (PA) is a common disease of children and seen in most of the developing countries. The exact pathogenesis of PA is still not well established. Some cases of PA have been associated with atopic dermatitis, while most cases have no association with it.
Objectives:
The objective was to evaluate the role played by zinc (Zn) in the pathogenesis of PA.
Patients and Methods:
Sixty patients suffering from PA were included in the study, and 30 apparently healthy individuals of matching age and sex were recruited as a control group. Serum Zn, hemoglobin, and albumin were measured in both groups. In addition, skin phototype and body mass index were recorded. The American Academy Criteria of atopic dermatitis diagnosis were applied to the participants in this study. PA patients were examined dermatologically with a recording of the site, size, and number of lesions.
Results:
There was no difference in the presence of atopic dermatitis between the patient and control groups (
P
= 0.672). PA lesions were detected in the faces of all patients. There were no statistically significant differences between patients and controls regarding serum hemoglobin concentration (
P
= 0.763) or serum albumin (
P
= 0.487). The serum level of Zn was lower in patients with PA than controls (
P
< 0.001) with statistically significant positive correlations with both numbers and size of PA lesions (
P
< 0.001 and
P
= 0.011, respectively).
Conclusions:
The present study showed that Zn may have a role in PA, and oral supplementation with Zn may be considered as a therapeutic approach in this disease.
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REVIEW ARTICLE
Orange–brown chromonychia, a novel finding in Kawasaki disease: 10 years since the first publication
Priyankar Pal, Mandira Roy, Alolika Nandi, Nazneen Ahmed
July-September 2020, 21(3):161-163
DOI
:10.4103/ijpd.IJPD_19_20
Red/orange–brown transverse nail bed lines in the acute phase of Kawasaki disease (KD) was a new clinical finding reported initially in 2010. Since then, it has been universally and consistently described in the acute phase of KD and may act as an accessory clinical clue in diagnosis. This article tries to review the clinical implication and the various reports citing this finding over the last 10 years.
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REVIEW OF CURRENT LITERATURE
Hot topics in pediatric dermatology
Anubha Dev, Rahul Mahajan
July-September 2020, 21(3):164-166
DOI
:10.4103/ijpd.IJPD_83_20
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ORIGINAL ARTICLES
Clinical and molecular characterization of lipoid proteinosis in three Indian families
Sahana M Srinivas, Madhuri Maganthi, Priya Jeevamani Chandrasekaran, Aruna Gowdra, Raghupathy Palany
July-September 2020, 21(3):167-173
DOI
:10.4103/ijpd.IJPD_9_20
Background:
Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized by deposition of hyaline material in the skin, mucous membrane, and multiple organs resulting in varied manifestations such as scarring and thickening of the skin, beaded papules, and hoarseness of voice. It results from mutations in the gene encoding extracellular matrix protein 1 (
ECM1
). The objectives of this study are to find the mutation spectrum of the
ECM1
gene in the Indian children and study the genotype-phenotype correlation.
Materials and Methods:
This pilot study included three unrelated Indian families with the clinical diagnosis of LP. Next-generation sequencing was done to look for
ECM1
gene mutations in the proband and was confirmed by Sanger sequencing in their siblings and parents. Chromosomal microarray was done wherever necessary.
Results:
All six children from three unrelated consanguineous families had characteristic clinical features of LP. Two children in family 1 exhibited systemic features like temporal lobe epilepsy in one and central precocious puberty in the other. One child from family 1 and one child from family 3 had short stature. Genetic analysis revealed novel homozygous missense variation in exon 7 (c.856T>C) in family 1 and homozygous nonsense variation in exon 8 (c.1327C>T) in family 2 of the
ECM1
gene. Family 3 revealed a large homozygous deletion of the
ECM1
gene which has not been previously described.
Conclusion:
All the three families had clinical heterogeneity. This study documented two novel mutations in the
ECM1
gene. Skin severity and systemic involvement were associated with missense mutation. Confirmation of
ECM1
gene mutation is necessary for proper genetic counseling.
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A study on clinical spectrum of pigmentary alterations among the pediatric population
Sameer Abrol, Rohini Sharma
July-September 2020, 21(3):174-177
DOI
:10.4103/ijpd.IJPD_1_19
Background:
Human skin color is the result of a complex interplay of various intrinsic and extrinsic factors and has great heterogeneity across the globe. It also carries an esthetic value with it, and any deviation from the normal may bear immense psychological and social implications, especially among the pediatric population where it can even be a sign of systemic diseases.
Aim:
The aim was to study clinical and epidemiological patterns of hyper and hypo/depigmentary disorders among children.
Materials and Methods:
This was a prospective study where 250 individuals ≤18 years were taken up for the study. A detailed history and clinical examination was done, and relevant investigations were carried out. The data were statistically analyzed and inferences were drawn. Results: The females outnumbered the males with 136 females and 114 males. The youngest age noted was 3 months and the oldest was 17 years. There were 118 cases of hyperpigmentary disorders, and the rest 132 patients presented with hypopigmentary and depigmented disorders. The most common hyperpigmentary disorders seen were postinflammatory hyperpigmentation, periorbital melanoses, pigmentary mosaicism, and café au lait macules. Among the hypo/depigmentary disorders, most common were pityriasis alba (39, 29.5%), followed by vitiligo seen in (35, 26.5%) and postinflammatory hypopigmentation (30, 22.7%).
Conclusion:
This study helped us in giving a detailed insight regarding the pigmentary alterations among the pediatric population in this area, thus aiding in prompt diagnosis among various differentials. Various aggravating and predisposing factors were also noted down which could be helpful in the prevention of some of these conditions.
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CASE REPORTS
Eruptive vellus hair cyst: Unveiling the diagnostic features
Rashmi Agarwal, BS Chandrashekar, Prarthana B Desai
July-September 2020, 21(3):194-196
DOI
:10.4103/ijpd.IJPD_12_20
Eruptive vellus hair cyst (EVHC) is a rare developmental abnormality of the vellus hair follicles presenting in children and adolescents as multiple, asymptomatic papules over the chest, axillae, and buttocks. Clinically, it can easily be misdiagnosed as comedonal acne, keratosis pilaris, steatocystoma multiplex, syringomas, milia, lichen nitidus, perforating folliculitis, and molluscum contagiosum. Here, we report a 4-year-old girl who was being treated as a case of steroid-induced folliculitis and was later diagnosed with EVHC based on dermoscopic features and confirmed by histopathological examination. Dermoscopy of EVHC shows the presence of homogenous blue areas, round or oval yellowish structures, with occasional erythematous halos and cystic openings in the epidermis. We report this case to emphasize the role of dermoscopy in early diagnosis of eruptive vellus hair cyst which is a rare condition and can be missed easily. Dermoscopy, being a non-invasive and painless diagnostic tool, can prove to be a useful, particularly in children for differentiating EVHC from its mimickers, thus avoiding the need for biopsy.
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Giant congenital melanocytic nevus with neurotized lesions mimicking neurofibromas – A rare presentation
Sudharani Chintagunta, Priyanka Jaju, Pragathi Sankineni
July-September 2020, 21(3):197-199
DOI
:10.4103/ijpd.IJPD_11_20
Giant congenital melanocytic nevus (GCMN) is a deeply pigmented lesion, often associated with hypertrichosis and multiple scattered satellite lesions. During infancy apart from textural changes, rapidly growing “proliferative nodules” mimicking melanoma can occur in the nevus. Areas of the nevus may be infiltrated by an overgrowth of fat or nerve tissue, so-called lipomatous or neurotized areas, respectively, common in larger nevi. We report a case of GCMN associated with multiple neurotized areas mimicking large neurofibromas, a rare phenomenon.
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Childhood suction purpura: Analysis of seven cases
Omer Kutlu, Serkan Düzayak
July-September 2020, 21(3):218-220
DOI
:10.4103/ijpd.IJPD_129_19
In this case series, five girls and two boys presented with purpuric-ecchymotic lesions that appeared around their lips. All patients were under the age of 15. While patients did not reveal any history of trauma at the beginning, they later accepted a history of sucking their lips inside their mouths or suctioning cups. In addition to negative routine laboratory tests including parvovirus in these patients, the lesions disappeared in several days. To the best of our knowledge, childhood suction purpura was examined for the first time in this case series.
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LETTERS TO EDITOR
Terra firma-forme dermatosis following episode of irritant contact dermatitis
Abhijit Saha, Rajib Malakar, Raghubir Baherjee, Sandipan Dhar
July-September 2020, 21(3):241-242
DOI
:10.4103/ijpd.IJPD_6_20
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CASE REPORTS
Recurrent urinary retention: An unusual presentation of laryngo-onycho-cutaneous syndrome
Aradhana Sood, Anuj Bhatnagar, Amit Aggarwal, Neerja Saraswat
July-September 2020, 21(3):200-202
DOI
:10.4103/ijpd.IJPD_15_19
Laryngo-onycho-cutaneous (LOC) first described by Shabbir in 1986 in Muslim families from Punjab is a rare autosomal recessive disorder characterized by increased skin and mucous membrane fragility associated with exuberant granulation. The 4
th
International Consensus Meeting on “Diagnosis and Classification of Epidermolysis Bullosa” classifies it as a localized form of Junctional Epidermolysis Bullosa (JEB-LOC Syndrome) with mutations in α3 chain of Laminin 332. While laryngeal, ocular, and cutaneous involvement in these cases has been widely reported, urinary tract involvement is relatively rare. We report a case of JEB-LOC syndrome in a child from South India with extensive urethral involvement.
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LETTERS TO EDITOR
Postdengue fever transient generalized hyperpigmentation with islands of normal skin and chik sign
Ani P Patel, Vidhi S Chandibhamar, Jigna K Padhiyar, Nayan H Patel
July-September 2020, 21(3):252-254
DOI
:10.4103/ijpd.IJPD_126_19
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CASE REPORTS
Palmo-plantar keratoderma with debilitating pruritus
Vandana Kataria, Chander Grover, Deepika Pandhi
July-September 2020, 21(3):187-190
DOI
:10.4103/ijpd.IJPD_4_20
We describe two siblings with diffuse, mutilating palmo-plantar keratoderma suggestive of Olmsted syndrome, with significantly compromised quality of life in the form of inability to walk and grasp objects. This was accompanied by severe pruritus and erythromelalgia-like symptoms. The keratoderma responded to acitretin therapy but there was paradoxical worsening of burning and pruritus which were further disabling. The poor response to medical and phototherapy in relieving these symptoms is described.
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Erythrokeratoderma en cocardes – A rare phenotype
P Arunprasath, Reena Rai, G Umamaheswari
July-September 2020, 21(3):191-193
DOI
:10.4103/ijpd.IJPD_16_20
Erythrokeratodermas are disorders of keratinization with two major types, namely erythrokeratodermia variabilis and symmetrical progressive erythrokeratoderma. Apart from the two main types, rare variants include erythrokeratoderma en cocardes (EEC), erythokeratoderma with erythema gyratum repens-like lesions, erythema annulare centrifugum-like lesions, and reticulate erythrokeratoderma. Herein, we report a rare case of EEC with associated palmoplantar keratoderma, the association which has not been described in previous reports.
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Cutis marmorata telangiectatica congenita with limb defects, cleft palate, and ambiguous genitalia
Manish Jain, Safa Patrick, Sumit Kar, Prachi Gawande
July-September 2020, 21(3):212-214
DOI
:10.4103/ijpd.IJPD_114_19
Cutis marmorata telangiectatica congenita (CMTC) is an uncommon, congenital, vascular malformation first described by van Lohuizen in 1922. CMTC is an infrequently reported congenital cutaneous disorder and is usually present at birth but can appear up to 3 months to 2 years of age. Hereby, we report a case of a 2-day-old infant with CMTC involving trunk with rarely reported congenital anomaly involving multiple system, i.e., musculoskeletal, cardiovascular, pulmonary, ophthalmic, excretory, oropharyngeal, and reproductive system.
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LETTERS TO EDITOR
Dermoscopic dirty scalp of darier's disease
Subrata Malakar, Harshal Ranglani, Surit Malakar
July-September 2020, 21(3):245-247
DOI
:10.4103/ijpd.IJPD_113_19
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CASE REPORTS
Primary lymphangioma circumscriptum around external urethral meatus in a male child: A rare presentation
Jayanti Singh, Surabhi Dayal, Janshruti Mothsra, Priyadarshini Sahu
July-September 2020, 21(3):206-208
DOI
:10.4103/ijpd.IJPD_21_20
Primary lymphangioma circumscriptum (LC) is a superficial lymphatic malformation, presenting as multiple fluid-filled grouped vesicular lesions which may be associated with slight hemorrhages. We report a rare case of primary LC with exclusive involvement of area around the external urethral meatus in a 10-year-old male child. We treated the patient with radiofrequency ablation under topical anesthesia with eutectic mixture of local anesthetics (EMLA). No recurrence has been observed in the past 1 year. LC must be included in differentials when presented with vesicular lesions near the external urethral meatus in male pediatric patients.
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Rare association of juvenile xanthogranuloma and acute lymphoblastic leukemia
Palvi Singla, Rima Joshi, Bela J Shah
July-September 2020, 21(3):209-211
DOI
:10.4103/ijpd.IJPD_49_19
Juvenile xanthogranuloma (JXG) is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. It is seen in combination with juvenile chronic myelomonocytic leukemia and/or neurofibromatosis type 1. The association with acute lymphoblastic leukemia (ALL) is rarely seen. We present a 2-year-old boy who had this rare combination and presented with multiple tan-orange-colored macules, papules, and nodules over the upper body and distal aspect of lower limbs for 4 months of age. The histologic evaluation and immunohistochemistry analysis resulted in the diagnosis of JXG. Bone marrow biopsy showed lymphoblastosis with marked suppression of erythroid and myeloid cells, suggesting ALL.
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LETTERS TO EDITOR
Sucking pads – A report of two cases with dermoscopic findings
Anand Lamoria, Aditi Agrawal, Alpana Mohta, Sandeep Pachar
July-September 2020, 21(3):247-248
DOI
:10.4103/ijpd.IJPD_1_20
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CASE REPORTS
Annular pattern of generalized granuloma annulare in an infant
Swetalina Pradhan, Subhra Dhar, Sandipan Dhar, Rohit Kumar Singh
July-September 2020, 21(3):203-205
DOI
:10.4103/ijpd.IJPD_20_20
Granuloma annulare (GA) is a benign granulomatous dermatosis. Clinically, it has been classified into localized, generalized, subcutaneous, macular, erythematous, and perforating types. Generalized GA (GGA) is an unusual pattern of GA reported mostly in adults aged 50 years or over and children aged about 10 years. Occurrence in infants is very rare and few cases of papular GGA have been reported in infants. We report a case of annular pattern of GGA in a 3-month-old infant. This is the first case report of annular pattern GGA in an infant.
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LETTERS TO EDITOR
Langerhans cell histiocytosis: Can dermoscopy help in diagnosis?
Yasmeen Jabeen Bhat, Insha Latif, Rohi Wani, Amaan Ullah Daing, Iffat Hassan
July-September 2020, 21(3):243-245
DOI
:10.4103/ijpd.IJPD_22_19
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CASE REPORTS
Dermoscopy deduced “neither pilus nor pores”: Christ-siemens-touraine syndrome: A case report
Priyanka Suresh Jaju, Mahajabeen Madarkar, Balachandra S Ankad, Aakash Gupta
July-September 2020, 21(3):224-228
DOI
:10.4103/ijpd.IJPD_115_18
Ectodermal dysplasia (ED) is used to define a group of inherited disorders characterized by the presence of abnormalities in two or more ectodermal derived structures, including hair, teeth, nails, or sweat glands. A 2-month-old boy presented with complaints of reduced scalp hair growth and loss of eyebrows since birth. He had a history of recurrent high fever and had been admitted twice for the same. Clinical examination of the patient revealed a fine, sparse, light-colored, short and dry hair over the scalp, with the absence of eyebrows, and eyelashes. The skin was smooth, dry with a prominent forehead and protuberant lips. Growth and developmental history were not significant. Trichoscopy showed absence or markedly reduced number of white dots. It corresponded to a finding of hypoplastic follicles with the absence of eccrine and sebaceous glands; these findings were consistent with histopathology. Dermoscopy is a noninvasive technique which aids in the clinical diagnosis of Christ-Siemens-Touraine syndrome by correlating clinical features histopathologically.
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A rare vasculitis with a dramatic presentation: Acute hemorrhagic edema of infancy
Vineet Relhan, Jaspriya Sandhu, Vijay Kumar Garg, Nita Khurana
July-September 2020, 21(3):215-217
DOI
:10.4103/ijpd.IJPD_84_18
Acute hemorrhagic edema of infancy is a disease marked by its dramatic presentation of purpuric plaques in a cockade or targetoid pattern. A 1-year-old boy was brought by his mother to our outpatient department with large purpuric plaques in annular and cockade pattern over the cheeks and bilateral lower limbs. Both the pinna showed purpura in a peculiar reticulate pattern, with vesiculation seen at the margin of the lesions along with mild edema. The skin biopsy showed cutaneous small-vessel vasculitis; direct immunofluorescence showed fibrinogen deposits around the small cutaneous vessels. The unusual features of our case were the reticulate pattern of purpura seen over the ears.
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LETTERS TO EDITOR
Dermatoscopic findings of pityriasis lichenoides et varioliformis acuta
Anuj Bhut, Aishni Shah, Pragya Ashok Nair
July-September 2020, 21(3):249-250
DOI
:10.4103/ijpd.IJPD_115_19
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CASE REPORTS
Subcutaneous phycomycosis involving the anterior abdominal wall in an immunocompetent boy successfully treated with potassium iodide
Angoori Gnaneshwar Rao, Vangali Srikanth Reddy, M Tejal, M Divya
July-September 2020, 21(3):229-231
DOI
:10.4103/ijpd.IJPD_17_19
Subcutaneous phycomycosis is a chronic deep fungal infection caused by
Basidiobolus ranarum
, which usually occurs in children, predominantly affecting males. Herein, we report subcutaneous phycomycosis in a 3-year-old boy who presented with a gradually progressive painless swelling over the anterior abdomen of 20-day duration. Lesional biopsy confirmed the diagnosis of subcutaneous phycomycosis which revealed multiple well-defined granulomas composed of histiocytes, epithelioid cells, and multinucleate giant cells with broad nonseptate hyphae stained with Gomori methenamine silver stain. The child was managed with a saturated solution of potassium iodide which completely melted the swelling.
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LETTERS TO EDITOR
Macrocephaly – Capillary malformation: A rare association with linear and reticulate portwine stain
Priya Jeevamani Chandrasekaran, Sahana M Srinivas, Nijaguna Nanjundappa
July-September 2020, 21(3):251-252
DOI
:10.4103/ijpd.IJPD_121_19
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© Indian Journal of Paediatric Dermatology | Published by Wolters Kluwer -
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Online since 1st September, 2011