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CASE REPORT
Year : 2021  |  Volume : 22  |  Issue : 2  |  Page : 160-161

Successful treatment of recalcitrant generalized pustular psoriasis in a young child with interleukin-36 receptor antagonist mutation with secukinumab monotherapy


Department of Paediatrics, Paediatric Dermatology Unit, Women and Children Hospital, Kuala Lumpur, Malaysia

Correspondence Address:
Henrietta Albela
Department of Paediatrics, Paediatric Dermatology Unit, Women and Children Hospital, Jalan Pahang 50586, Kuala Lumpur
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpd.ijpd_3_21

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Generalized pustular psoriasis (GPP) is a severe, life-threatening form of psoriasis. Deficiency of interleukin (IL)-36 receptor antagonist has been found in a subset of patients with GPP, which is usually more difficult to treat with conventional treatment. We report a case of a 4-year-old Malaysian-Chinese boy with GPP and homozygous mutation at c.115+6T>C within the interleukin-36 receptor antagonist (IL36RN) gene, who was treated successfully with off-label use of secukinumab monotherapy after failure of treatment with acitretin and cyclosporine A.


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