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Year : 2020  |  Volume : 21  |  Issue : 3  |  Page : 209-211

Rare association of juvenile xanthogranuloma and acute lymphoblastic leukemia

Department of Dermatology, B J Medical College, Civil Hospital, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Palvi Singla
Room No. 408a, New PG Hostel, Phase 2, Civil Hospital, Asarwa, Ahmedabad - 380 016, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpd.IJPD_49_19

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Juvenile xanthogranuloma (JXG) is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. It is seen in combination with juvenile chronic myelomonocytic leukemia and/or neurofibromatosis type 1. The association with acute lymphoblastic leukemia (ALL) is rarely seen. We present a 2-year-old boy who had this rare combination and presented with multiple tan-orange-colored macules, papules, and nodules over the upper body and distal aspect of lower limbs for 4 months of age. The histologic evaluation and immunohistochemistry analysis resulted in the diagnosis of JXG. Bone marrow biopsy showed lymphoblastosis with marked suppression of erythroid and myeloid cells, suggesting ALL.

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