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Year : 2020  |  Volume : 21  |  Issue : 3  |  Page : 178-183

Zinc has a role in pathogenesis of pityriasis alba

1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt

Date of Submission03-Nov-2019
Date of Decision24-Dec-2019
Date of Acceptance26-Apr-2020
Date of Web Publication30-Jun-2020

Correspondence Address:
Dr. Essam M Akl
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, P. O. 13518, Benha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpd.IJPD_109_19

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Background: Pityriasis alba (PA) is a common disease of children and seen in most of the developing countries. The exact pathogenesis of PA is still not well established. Some cases of PA have been associated with atopic dermatitis, while most cases have no association with it. Objectives: The objective was to evaluate the role played by zinc (Zn) in the pathogenesis of PA. Patients and Methods: Sixty patients suffering from PA were included in the study, and 30 apparently healthy individuals of matching age and sex were recruited as a control group. Serum Zn, hemoglobin, and albumin were measured in both groups. In addition, skin phototype and body mass index were recorded. The American Academy Criteria of atopic dermatitis diagnosis were applied to the participants in this study. PA patients were examined dermatologically with a recording of the site, size, and number of lesions. Results: There was no difference in the presence of atopic dermatitis between the patient and control groups (P = 0.672). PA lesions were detected in the faces of all patients. There were no statistically significant differences between patients and controls regarding serum hemoglobin concentration (P = 0.763) or serum albumin (P = 0.487). The serum level of Zn was lower in patients with PA than controls (P < 0.001) with statistically significant positive correlations with both numbers and size of PA lesions (P < 0.001 and P = 0.011, respectively). Conclusions: The present study showed that Zn may have a role in PA, and oral supplementation with Zn may be considered as a therapeutic approach in this disease.

Keywords: Diet, pityriasis alba, zinc

How to cite this article:
Elesawy FM, Akl EM, Abdel Halim WA. Zinc has a role in pathogenesis of pityriasis alba. Indian J Paediatr Dermatol 2020;21:178-83

How to cite this URL:
Elesawy FM, Akl EM, Abdel Halim WA. Zinc has a role in pathogenesis of pityriasis alba. Indian J Paediatr Dermatol [serial online] 2020 [cited 2020 Nov 25];21:178-83. Available from: https://www.ijpd.in/text.asp?2020/21/3/178/288481

  Introduction Top

Pityriasis alba (PA) is a common dermatological disease, characterized by asymptomatic slightly scaly ill-defined hypopigmented skin patches.[1] PA occurs predominantly in children between 3 and 16 years, and both genders are equally affected.[2] The pathogenesis of PA is still not fully well established,[3] and several theories have been suggested such as considering it a part of atopic dermatitis, implicating infective agents, or environmental influences.[4] Nevertheless, in most cases, it is related to overexposure to sunlight, especially in darker skin phototype.[5]

Zinc (Zn) is one of the most essential trace elements in the human body.[6] Zn has multiple immunological, endocrinal, reproductive, antioxidant,[7] and melanogenesis functions.[8]

Aim of the work

The objective was to evaluate the serum level of Zn in patients with PA.

  Patients and Methods Top

Ethical approval

This study was done after approval of the Medical Research Ethics Committee on October 2018. The legal guardians of the children involved in this study were informed about the nature of this study and had given their informed consent. The infants included in this study were not subjected to any harmful procedures, and their personal data were secured.

This work was a case–control comparative study done from November 2018 to April 2019. This study included 90 children who were divided into two groups: Group A included sixty children with PA and Group B included thirty age- and sex-matched apparently healthy children from the same area of the patients. Patients suffer from PA with more than 2 months duration and who did not receive either systemic or topical treatment for PA for the last month were included in the study. Patients with systemic autoimmune diseases; diabetes mellitus; hepatic, renal, hematological, and chronic infectious diseases; or malignancy were excluded from the study.

Age, sex, body mass index (BMI), and skin phototype were determined in patients and controls. Complete dermatological examination was done in all patients to determine the site, size, and distribution of PA. PA was diagnosed clinically in patients if lesions were hypopigmented, have fine scaly macules and/or patches; ill-defined margins; and absence of preceding inflammatory lesions.[9] In addition, the diagnosis of atopic dermatitis in PA patients was done using the American Academy of Dermatology Diagnostic Criteria.[10]

The laboratory procedures included serum hemoglobin concentration, serum albumin, serum Zn measurements, and stool analysis.

5 millimeters of venous blood sample was taken from the participants in this study and was used for laboratory investigations. The blood samples were divided into two parts: the first part was used freshly to calculate serum hemoglobin concentration by Sysmex XP-300® (Sysmex Corporation, Kobe, Japan), and the second part was allowed to clot, then centrifuged (5000 rpm, 25 min, 25°C), and the separated serum was used to measure both albumin and Zn. Serum albumin was measured using a Roche Modular D2400 system (Roche Diagnostics, Indianapolis, IN, USA), and the reference range of our institution is 3.5–5 g/dl. Serum Zn was measured spectrophotometrically using Zn fluid monoreagent (Centronic GmbH, Wartenberg, Germany). Stool analysis, both macroscopic and microscopic, was done to both patients and controls.

Statistical analysis

Data of this study were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software software, IBM© Armonk, NY, U.S.A computer program version 20 for Microsoft Window 7® 64 bit. The t-test was used to compare the numerical data of normally distributed variables, whereas categorical variable differences were analyzed with Chi-square test. The Spearman's correlation test was used to examine correlations. Logistic regression analysis was used for prediction of risk factors. Receiver operating characteristic (ROC) curve was used to categorize cases into one of the two groups. P ≤ 0.05 was considered statistically significant.

  Results Top

The demographic and clinical data of the participants in this study are summarized in [Table 1]. There were no statistically significant differences between the patients and controls regarding age (P = 0.604), BMI (P = 0.559), sex (P = 0.760), skin phototype (P = 0.211), high sun exposure frequency (P = 0.837), or having atopic dermatitis (P = 0.672).
Table 1: Demographic data and comparison between pityriasis alba patients and control regarding age, sex, skin phototype, sun exposure, and atopic dermatitis

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All the patients had a PA in the face (100%), and in addition to the face affection, some patients had PA in the neck (6.7%) and arms (3.33%), [Table 1] and [Figure 1], [Figure 2], [Figure 3], [Figure 4].
Figure 1: A 8-year-old female child with multiple patches of pityriasis alba

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Figure 2: A 5-year-old male child with a large patch of pityriasis alba

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Figure 3: A 12-year-old male child with multiple patches of pityriasis alba

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Figure 4: A 6-year-old female child with multiple patches of pityriasis alba

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Comparing laboratory data of PA patients and controls, there were no statistically significant differences of infestation by Oxyuris vermicularis (P = 0.09) and Entamoeba histolytica (P = 0.134). Although there were no statistically significant differences regarding the serum albumin level (P = 0.487) or serum hemoglobin concentration (P = 0.763), there was a statistically significant difference between the two groups regarding serum Zn concentration (P < 0.001) [Table 2].
Table 2: Comparison between pityriasis alba patients and control regarding laboratory data

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Using the Spearman's correlation test, low serum Zn level showed statistically significant negative correlations with the number (P < 0.001) and size of lesions of PA (P = 0.011) [Figure 5] and [Figure 6].
Figure 5: Correlation between the serum level of zinc and the number of pityriasis alba lesions

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Figure 6: Correlation between the serum level of zinc and the size of pityriasis alba lesions

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Logistic regression analysis was conducted for prediction of PA within controls, using age, gender, BMI, laboratory data, and serum Zn as covariates. Low serum Zn was considered as a risk factor for the development of PA within controls (P < 0.001) [Table 3].
Table 3: Regression analysis for prediction of pityriasis alba within controls

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Using the ROC curve, serum level of Zn<107 μg/dL was significantly associated with higher numbers and size of PA in patients [Table 4] and [Figure 7].
Table 4: Area under receiver operating characteristic curve and performance criteria of serum zinc for discrimination between pityriasis alba case and control groups

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Figure 7: Receiver operating characteristic curve analysis between the serum level of zinc and pityriasis alba occurrence

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  Discussion Top

Zn is required for hundreds of metabolically related enzymes, transcription factors, and gene expression.[11] There is no specialized Zn storage in the body, and its daily intake is required due to its rapid turnover.[12] Meat and fish are the important sources of Zn with higher bioavailability than plant sources, and intake of folate, fiber, and phytochemicals reduces its absorption.[13] Serum Zn is largely bound to albumin, α2-macroglobulin, and transferrin.[14] The most common cause of Zn deficiency is malnutrition, and >17% worldwide population (especially in developing countries) have Zn deficiency.[15]

The results of this study showed that a low serum level of Zn is associated with PA. Zn is found in human skin with a concentration in the epidermis (60 μg/g) that is more than that in the dermis (40 μg/g).[16] Zn has multiple functions in human skin such as keratinocyte proliferation and differentiation, melanocyte function, and immune regulations.[17] Serum Zn deficiency has been reported in hypopigmented[18],[19] and dry, rough skin disorders,[20] which are commonly seen in PA(1).

A minority of patients enrolled in this study had atopic dermatitis. PA is classified into endemic PA that has an inflammatory nature,[21] occurring in developing countries,[22] and hypopigmentation type, occurring in atopic dermatitis infants in developed countries.[23]

All of our patients had PA on the face. This indicates the possible role of overexposure to the sun in PA pathogenesis.[24] The decreased Zn concentration may limit the protection of keratinocyte to ultraviolet radiation[25] and can facilitate inflammation.[26] In addition, oral Zn supplementations have been used in multiple skin inflammatory diseases.[27]

There was no significant difference in serum hemoglobin and albumin concentration in this study, and this was similar to other studies in developing countries and in vegetarians.[28],[29] As there was no significant difference in stool analysis between the participants, the low serum Zn can be attributed to low meat and high plant diets, which contain large quantities of phytate and phytic acid that decrease intestinal absorption of Zn.[30]

Zn has a role in skin pigmentation,[31],[32] and low serum Zn may induce skin hypopigmentation.[33] In addition, low serum Zn has been associated with skin inflammation.[34] Both hypopigmentation and skin inflammation are essential features of PA.[5]

  Conclusions Top

The serum level of Zn is lower in patients with PA with a positive correlation with disease severity in the form of the size and number of lesions. Oral Zn supplementations may be used in cases of PA.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

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  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]

  [Table 1], [Table 2], [Table 3], [Table 4]


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