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Year : 2019  |  Volume : 20  |  Issue : 2  |  Page : 93-100

Prevention of atopic dermatitis: Etiological considerations and identification of potential strategies

1 Department of Dermatology, Monash University, Eastern Health, Box Hill; Department of Paediatrics, University of Melbourne; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Melbourne, Australia
2 Murdoch Children's Research Institute, Royal Children's Hospital, Parkville; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia

Correspondence Address:
Prof. John C Su
Level 2/5 Arnold St., Box Hill 3128, Victoria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpd.IJPD_10_19

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Research during the last decade has given many new insights into factors contributing to the development and evolution of atopic dermatitis (AD). Factors identified include skin barrier defects, proinflammatory predispositions, anomalies in the microbiome, and some environmental influences. There is now the possibility of personalizing therapy and potentially, of disease prevention. However, discerning the respective roles of early factors leading to AD development is complex. Stringent analysis for confounders must precede attribution of causality to any factor. This review examines current understandings of AD pathogenesis and related research approaches in AD primary prevention.

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