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Year : 2017  |  Volume : 18  |  Issue : 4  |  Page : 306-309

Erythroderma: An association or a manifestation extraordinary of hyper-immunoglobulin E

1 Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, New Delhi, India
2 Department of Pathology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, New Delhi, India

Correspondence Address:
Virendra N Sehgal
Dermato-Venerology (Skin/VD) Center, Sehgal Nursing Home, A/6 Panchwati, New Delhi - 110 033
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpd.IJPD_51_17

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Erythroderma/generalized exfoliative dermatitis, presenting with intensely itchy, dry, scaly, widespread erythema covering whole of the skin surface is reported, the diagnosis of which was primarily clinical but was supplemented by histopathology. Other investigations such as hemogram, immunoglobulin E (IgE), and serum fluorescent enzyme immunoassay (FEIA) were supportive; while IgE was high, serum FEIA was extraordinary high. Identifying it as a clinical pearl of hyper-IgE syndrome, recovery of heavy coloniz ation of Klebsiella pneumoniae, anaerobic Gram-negative bacteria, was contrastingly unique responding affectively to metronidazole, a drug specific for the purpose.

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