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ORIGINAL ARTICLE
Year : 2014  |  Volume : 15  |  Issue : 2  |  Page : 74-78

308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo


Department of Dermatology, Cutis, Academy of Cutaneous Sciences, Bangalore, India

Correspondence Address:
B S Chandrashekar
#5/1, 4th Main Road, MRCR Layout, Near Veeresh Theatre Behind Godrej Interio, Vijaynagar, Bengaluru - 560 040, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2319-7250.139503

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Background: Vitiligo is a chronic, polygenic dyschromia that presents with multiple depigmented macules and patches. Among the various therapeutic modalities for treatment of vitiligo in children, phototherapy as one of the mainstay treatments has varying therapeutic efficacy. There is limited data regarding the use of combination of tacrolimus and 308 nm excimer lamp for treatment of vitiligo in children. Aim: The aim of the present study is to retrospectively assess the efficacy and tolerability of 308 nm Excimer lamp in combination with topical tacrolimus to treat vitiligo in children below 17 years with skin type III, IV and V. Methods: Case sheets and photographs of 47 vitiligo patches from 24 children (male = 9, female = 15), <17 years were evaluated in this study. Data of patients with active disease and stable vitiligo not treated previously were chosen for this study. The patches were treated with topical tacrolimus daily and excimer lamp thrice weekly, for a maximum of 20 sittings. Results: Of the 47 patches, 35 patches achieved repigmentation accounting to 74.4% of the total patches. The repigmentation response was good in ultraviolet (UV) sensitive areas but minimal in UV resistant areas. All the patches retained pigmentation during the follow-up period of 12-18 months. Conclusion: The degree of repigmentation achieved with topical tacrolimus and excimer lamp in a period of 4-6 weeks is much higher than other contemporary vitiligo therapies in children. This dual therapy of topical tacrolimus and 308 nm Excimer lamp is a safe and effective therapy showing an early response, for localized vitiligo in children.


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